Effects of Chronic Mild Stress in Female Bax Inhibitor-1-Gene Knockout Mice
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چکیده
منابع مشابه
Effects of Chronic Mild Stress in Female Bax Inhibitor-1-Gene Knockout Mice
OBJECTIVE The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress, and BI-1(-/-) mice exhibit increased sensitivity to tissue damage. The purpose of this study was to investigate the role of BI-1 in the pathogenesis of chronic mild stress (CMS)-induced depression-like behaviors in BI-1(-/-) mice. METHODS We delivered CMS for 2 ...
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The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress. It has been hypothesized that BI-1 protects against neuron degenerative diseases. In this study, BI-1⁻/⁻ mice showed increased vulnerability to chronic mild stress accompanied by alterations in the size and morphology of the hippocampi, enhanced ROS accumulation and an ER s...
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ژورنال
عنوان ژورنال: Clinical Psychopharmacology and Neuroscience
سال: 2012
ISSN: 1738-1088,2093-4327
DOI: 10.9758/cpn.2012.10.3.155